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Characterising the immune profile of the kidney biopsy at lupus nephritis flare differentiates early treatment responders from non-responders.

Lupus science & medicine

Parikh SV, Malvar A, Song H, Alberton V, Lococo B, Vance J, Zhang J, Yu L, Rovin BH.
PMID: 26629350
Lupus Sci Med. 2015 Nov 18;2(1):e000112. doi: 10.1136/lupus-2015-000112. eCollection 2015.

INTRODUCTION: The kidney biopsy is used to diagnose and guide initial therapy in patients with lupus nephritis (LN). Kidney histology does not correlate well with clinical measurements of kidney injury or predict how patients will respond to standard-of-care immunosuppression....

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Parikh SV, Malvar A, Song H, et al. Characterising the immune profile of the kidney biopsy at lupus nephritis flare differentiates early treatment responders from non-responders. Lupus Sci Med. 2015;2(1):e000112doi: 10.1136/lupus-2015-000112.
Parikh, S. V., Malvar, A., Song, H., Alberton, V., Lococo, B., Vance, J., Zhang, J., Yu, L., & Rovin, B. H. (2015). Characterising the immune profile of the kidney biopsy at lupus nephritis flare differentiates early treatment responders from non-responders. Lupus science & medicine, 2(1), e000112. https://doi.org/10.1136/lupus-2015-000112
Parikh, Samir V, et al. "Characterising the immune profile of the kidney biopsy at lupus nephritis flare differentiates early treatment responders from non-responders." Lupus science & medicine vol. 2,1 (2015): e000112. doi: https://doi.org/10.1136/lupus-2015-000112
Parikh SV, Malvar A, Song H, Alberton V, Lococo B, Vance J, Zhang J, Yu L, Rovin BH. Characterising the immune profile of the kidney biopsy at lupus nephritis flare differentiates early treatment responders from non-responders. Lupus Sci Med. 2015 Nov 18;2(1):e000112. doi: 10.1136/lupus-2015-000112. eCollection 2015. PMID: 26629350; PMCID: PMC4654163.
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Erratum: Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort.

Lupus science & medicine

[No authors listed]
PMID: 27335658
Lupus Sci Med. 2016 May 12;3(1):e000143corr1. doi: 10.1136/lupus-2015-000143corr1. eCollection 2016.

[This corrects the article DOI: 10.1136/lupus-2015-000143.].

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Erratum: Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort. Lupus Sci Med. 2016;3(1):e000143corr1doi: 10.1136/lupus-2015-000143corr1.
(2016). Erratum: Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort. Lupus science & medicine, 3(1), e000143corr1. https://doi.org/10.1136/lupus-2015-000143corr1
"Erratum: Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort." Lupus science & medicine vol. 3,1 (2016): e000143corr1. doi: https://doi.org/10.1136/lupus-2015-000143corr1
Erratum: Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort. Lupus Sci Med. 2016 May 12;3(1):e000143corr1. doi: 10.1136/lupus-2015-000143corr1. eCollection 2016. PMID: 27335658; PMCID: PMC4908918.
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Standardised incidence ratios (SIRs) for cancer after renal transplant in systemic lupus erythematosus (SLE) and non-SLE recipients.

Lupus science & medicine

Ramsey-Goldman R, Brar A, Richardson C, Salifu MO, Clarke A, Bernatsky S, Stefanov DG, Jindal RM.
PMID: 27335659
Lupus Sci Med. 2016 Jun 06;3(1):e000156. doi: 10.1136/lupus-2016-000156. eCollection 2016.

OBJECTIVE: We investigated malignancy risk after renal transplantation in patients with and without systemic lupus erythematosus (SLE).METHODS: Using the United States Renal Data System from 2001 to 2009, 143 652 renal transplant recipients with and without SLE contributed 585...

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Ramsey-Goldman R, Brar A, Richardson C, et al. Standardised incidence ratios (SIRs) for cancer after renal transplant in systemic lupus erythematosus (SLE) and non-SLE recipients. Lupus Sci Med. 2016;3(1):e000156doi: 10.1136/lupus-2016-000156.
Ramsey-Goldman, R., Brar, A., Richardson, C., Salifu, M. O., Clarke, A., Bernatsky, S., Stefanov, D. G., & Jindal, R. M. (2016). Standardised incidence ratios (SIRs) for cancer after renal transplant in systemic lupus erythematosus (SLE) and non-SLE recipients. Lupus science & medicine, 3(1), e000156. https://doi.org/10.1136/lupus-2016-000156
Ramsey-Goldman, Rosalind, et al. "Standardised incidence ratios (SIRs) for cancer after renal transplant in systemic lupus erythematosus (SLE) and non-SLE recipients." Lupus science & medicine vol. 3,1 (2016): e000156. doi: https://doi.org/10.1136/lupus-2016-000156
Ramsey-Goldman R, Brar A, Richardson C, Salifu MO, Clarke A, Bernatsky S, Stefanov DG, Jindal RM. Standardised incidence ratios (SIRs) for cancer after renal transplant in systemic lupus erythematosus (SLE) and non-SLE recipients. Lupus Sci Med. 2016 Jun 06;3(1):e000156. doi: 10.1136/lupus-2016-000156. eCollection 2016. PMID: 27335659; PMCID: PMC4908873.
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Patients with systemic lupus erythematosus and haematological malignancy at a tertiary care centre: timing, histopathology and therapy.

Lupus science & medicine

Knight JS, Blayney DW, Somers EC.
PMID: 25452880
Lupus Sci Med. 2014 Nov 14;1(1):e000051. doi: 10.1136/lupus-2014-000051. eCollection 2014.

OBJECTIVES: Patients with systemic lupus erythematosus (SLE) are at higher risk of haematological malignancies (HMs) than the general population. Most reports have focused on HM diagnosed after SLE, and have excluded concurrent and preceding diagnoses. Information on response to...

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Knight JS, Blayney DW, Somers EC. Patients with systemic lupus erythematosus and haematological malignancy at a tertiary care centre: timing, histopathology and therapy. Lupus Sci Med. 2014;1(1):e000051doi: 10.1136/lupus-2014-000051.
Knight, J. S., Blayney, D. W., & Somers, E. C. (2014). Patients with systemic lupus erythematosus and haematological malignancy at a tertiary care centre: timing, histopathology and therapy. Lupus science & medicine, 1(1), e000051. https://doi.org/10.1136/lupus-2014-000051
Knight, Jason S, et al. "Patients with systemic lupus erythematosus and haematological malignancy at a tertiary care centre: timing, histopathology and therapy." Lupus science & medicine vol. 1,1 (2014): e000051. doi: https://doi.org/10.1136/lupus-2014-000051
Knight JS, Blayney DW, Somers EC. Patients with systemic lupus erythematosus and haematological malignancy at a tertiary care centre: timing, histopathology and therapy. Lupus Sci Med. 2014 Nov 14;1(1):e000051. doi: 10.1136/lupus-2014-000051. eCollection 2014. PMID: 25452880; PMCID: PMC4246917.
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Association of age with health-related quality of life in a cohort of patients with systemic lupus erythematosus: the Georgians Organized Against Lupus study.

Lupus science & medicine

Plantinga L, Lim SS, Bowling CB, Drenkard C.
PMID: 27547440
Lupus Sci Med. 2016 Jul 19;3(1):e000161. doi: 10.1136/lupus-2016-000161. eCollection 2016.

OBJECTIVE: To examine whether older age was associated with lower health-related quality of life (HRQOL) among patients with systemic lupus erythematosus (SLE) and whether differential disease-related damage and activity explained these associations.METHODS: We used cross-sectional data on 684 patients...

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Plantinga L, Lim SS, Bowling CB, et al. Association of age with health-related quality of life in a cohort of patients with systemic lupus erythematosus: the Georgians Organized Against Lupus study. Lupus Sci Med. 2016;3(1):e000161doi: 10.1136/lupus-2016-000161.
Plantinga, L., Lim, S. S., Bowling, C. B., & Drenkard, C. (2016). Association of age with health-related quality of life in a cohort of patients with systemic lupus erythematosus: the Georgians Organized Against Lupus study. Lupus science & medicine, 3(1), e000161. https://doi.org/10.1136/lupus-2016-000161
Plantinga, Laura, et al. "Association of age with health-related quality of life in a cohort of patients with systemic lupus erythematosus: the Georgians Organized Against Lupus study." Lupus science & medicine vol. 3,1 (2016): e000161. doi: https://doi.org/10.1136/lupus-2016-000161
Plantinga L, Lim SS, Bowling CB, Drenkard C. Association of age with health-related quality of life in a cohort of patients with systemic lupus erythematosus: the Georgians Organized Against Lupus study. Lupus Sci Med. 2016 Jul 19;3(1):e000161. doi: 10.1136/lupus-2016-000161. eCollection 2016. PMID: 27547440; PMCID: PMC4964216.
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Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment.

Lupus science & medicine

Kurien BT, Harris VM, Quadri SM, Coutinho-de Souza P, Cavett J, Moyer A, Ittiq B, Metcalf A, Ramji HF, Truong D, Kumar R, Koelsch KA, Centola M, Payne A, Danda D, Scofield RH.
PMID: 26380101
Lupus Sci Med. 2015 Sep 08;2(1):e000114. doi: 10.1136/lupus-2015-000114. eCollection 2015.

OBJECTIVES: Commercial curcumin (CU), derived from food spice turmeric (TU), has been widely studied as a potential therapeutic for a variety of oncological and inflammatory conditions. Lack of solubility/bioavailability has hindered curcumin's therapeutic efficacy in human diseases. We have...

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Kurien BT, Harris VM, Quadri SM, et al. Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment. Lupus Sci Med. 2015;2(1):e000114doi: 10.1136/lupus-2015-000114.
Kurien, B. T., Harris, V. M., Quadri, S. M., Coutinho-de Souza, P., Cavett, J., Moyer, A., Ittiq, B., Metcalf, A., Ramji, H. F., Truong, D., Kumar, R., Koelsch, K. A., Centola, M., Payne, A., Danda, D., & Scofield, R. H. (2015). Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment. Lupus science & medicine, 2(1), e000114. https://doi.org/10.1136/lupus-2015-000114
Kurien, Biji T, et al. "Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment." Lupus science & medicine vol. 2,1 (2015): e000114. doi: https://doi.org/10.1136/lupus-2015-000114
Kurien BT, Harris VM, Quadri SM, Coutinho-de Souza P, Cavett J, Moyer A, Ittiq B, Metcalf A, Ramji HF, Truong D, Kumar R, Koelsch KA, Centola M, Payne A, Danda D, Scofield RH. Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment. Lupus Sci Med. 2015 Sep 08;2(1):e000114. doi: 10.1136/lupus-2015-000114. eCollection 2015. PMID: 26380101; PMCID: PMC4567741.
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Assessment of direct versus indirect magnetic bead-based T-cell isolation procedures followed by magnetic bead-based DNA isolation.

Lupus science & medicine

Rosenbaum A, Bleck E, Schneider M, Pongratz G, Vordenbäumen S.
PMID: 27547441
Lupus Sci Med. 2016 Jul 19;3(1):e000167. doi: 10.1136/lupus-2016-000167. eCollection 2016.

OBJECTIVE: To compare direct and indirect bead-based T-cell isolation followed by magnetic bead-based DNA isolation.METHODS: T-cells were isolated by direct or indirect selection with magnetic bead coated antbiodies followed by magnetic bead-based automated DNA isolation in 10 healthy subjects....

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Rosenbaum A, Bleck E, Schneider M, et al. Assessment of direct versus indirect magnetic bead-based T-cell isolation procedures followed by magnetic bead-based DNA isolation. Lupus Sci Med. 2016;3(1):e000167doi: 10.1136/lupus-2016-000167.
Rosenbaum, A., Bleck, E., Schneider, M., Pongratz, G., & Vordenbäumen, S. (2016). Assessment of direct versus indirect magnetic bead-based T-cell isolation procedures followed by magnetic bead-based DNA isolation. Lupus science & medicine, 3(1), e000167. https://doi.org/10.1136/lupus-2016-000167
Rosenbaum, Anna, et al. "Assessment of direct versus indirect magnetic bead-based T-cell isolation procedures followed by magnetic bead-based DNA isolation." Lupus science & medicine vol. 3,1 (2016): e000167. doi: https://doi.org/10.1136/lupus-2016-000167
Rosenbaum A, Bleck E, Schneider M, Pongratz G, Vordenbäumen S. Assessment of direct versus indirect magnetic bead-based T-cell isolation procedures followed by magnetic bead-based DNA isolation. Lupus Sci Med. 2016 Jul 19;3(1):e000167. doi: 10.1136/lupus-2016-000167. eCollection 2016. PMID: 27547441; PMCID: PMC4964240.
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Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments.

Lupus science & medicine

Askanase A, Li X, Pong A, Shum K, Kamp S, Carthen F, Aberle T, Hanrahan L, Daly P, Giles J, Merrill JT.
PMID: 25861457
Lupus Sci Med. 2015 Mar 04;2(1):e000075. doi: 10.1136/lupus-2014-000075. eCollection 2015.

OBJECTIVE: Current disease activity measures for systemic lupus erythematosus (SLE) are difficult to score or interpret and problematic for use in clinical practice. Lupus Foundation of America (LFA)-Rapid Evaluation of Activity in Lupus (REAL) is a pilot application composed...

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Askanase A, Li X, Pong A, et al. Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments. Lupus Sci Med. 2015;2(1):e000075doi: 10.1136/lupus-2014-000075.
Askanase, A., Li, X., Pong, A., Shum, K., Kamp, S., Carthen, F., Aberle, T., Hanrahan, L., Daly, P., Giles, J., & Merrill, J. T. (2015). Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments. Lupus science & medicine, 2(1), e000075. https://doi.org/10.1136/lupus-2014-000075
Askanase, Anca, et al. "Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments." Lupus science & medicine vol. 2,1 (2015): e000075. doi: https://doi.org/10.1136/lupus-2014-000075
Askanase A, Li X, Pong A, Shum K, Kamp S, Carthen F, Aberle T, Hanrahan L, Daly P, Giles J, Merrill JT. Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments. Lupus Sci Med. 2015 Mar 04;2(1):e000075. doi: 10.1136/lupus-2014-000075. eCollection 2015. PMID: 25861457; PMCID: PMC4378376.
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Disease activity patterns over time in patients with SLE: analysis of the Hopkins Lupus Cohort.

Lupus science & medicine

Györi N, Giannakou I, Chatzidionysiou K, Magder L, van Vollenhoven RF, Petri M.
PMID: 28243457
Lupus Sci Med. 2017 Feb 08;4(1):e000192. doi: 10.1136/lupus-2016-000192. eCollection 2017.

OBJECTIVE: To describe SLE disease activity patterns in the Hopkins Lupus Cohort.METHODS: Disease activity was studied in 1886 patients followed-up for 1-28 years. Disease activity patterns were defined using (1) Physician Global Assessment (PGA) and (2) modified SLE Disease...

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Györi N, Giannakou I, Chatzidionysiou K, et al. Disease activity patterns over time in patients with SLE: analysis of the Hopkins Lupus Cohort. Lupus Sci Med. 2017;4(1):e000192doi: 10.1136/lupus-2016-000192.
Györi, N., Giannakou, I., Chatzidionysiou, K., Magder, L., van Vollenhoven, R. F., & Petri, M. (2017). Disease activity patterns over time in patients with SLE: analysis of the Hopkins Lupus Cohort. Lupus science & medicine, 4(1), e000192. https://doi.org/10.1136/lupus-2016-000192
Györi, Noémi, et al. "Disease activity patterns over time in patients with SLE: analysis of the Hopkins Lupus Cohort." Lupus science & medicine vol. 4,1 (2017): e000192. doi: https://doi.org/10.1136/lupus-2016-000192
Györi N, Giannakou I, Chatzidionysiou K, Magder L, van Vollenhoven RF, Petri M. Disease activity patterns over time in patients with SLE: analysis of the Hopkins Lupus Cohort. Lupus Sci Med. 2017 Feb 08;4(1):e000192. doi: 10.1136/lupus-2016-000192. eCollection 2017. PMID: 28243457; PMCID: PMC5307372.
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Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands.

Lupus science & medicine

Ramachandran SM, Leventhal JS, Franco LG, Mir A, Walters RF, Franks AG.
PMID: 28331627
Lupus Sci Med. 2017 Mar 13;4(1):e000207. doi: 10.1136/lupus-2017-000207. eCollection 2017.

Subacute cutaneous lupus erythematosus (SCLE) is a well-defined subtype of lupus erythematosus, characterised by photosensitivity, annular and/or psoriasiform lesions, variable systemic involvement and presence of circulating SSA/anti-Ro antibodies. SCLE may be idiopathic or drug-induced. Both the idiopathic and drug-induced...

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Ramachandran SM, Leventhal JS, Franco LG, et al. Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands. Lupus Sci Med. 2017;4(1):e000207doi: 10.1136/lupus-2017-000207.
Ramachandran, S. M., Leventhal, J. S., Franco, L. G., Mir, A., Walters, R. F., & Franks, A. G. (2017). Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands. Lupus science & medicine, 4(1), e000207. https://doi.org/10.1136/lupus-2017-000207
Ramachandran, Sarika M, et al. "Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands." Lupus science & medicine vol. 4,1 (2017): e000207. doi: https://doi.org/10.1136/lupus-2017-000207
Ramachandran SM, Leventhal JS, Franco LG, Mir A, Walters RF, Franks AG. Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands. Lupus Sci Med. 2017 Mar 13;4(1):e000207. doi: 10.1136/lupus-2017-000207. eCollection 2017. PMID: 28331627; PMCID: PMC5353283.
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Assessment of the independent associations of IgG, IgM and IgA isotypes of anticardiolipin with thrombosis in SLE.

Lupus science & medicine

Domingues V, Magder LS, Petri M.
PMID: 27403332
Lupus Sci Med. 2016 Jun 20;3(1):e000107. doi: 10.1136/lupus-2015-000107. eCollection 2016.

OBJECTIVE: The Sydney classification criteria for antiphospholipid syndrome include lupus anticoagulant or moderate-to-high titre anticardiolipin IgG or IgM. We explored the association of all anticardiolipin isotypes, lupus anticoagulant and the combination with venous and arterial thrombosis.METHODS: Patients with systemic...

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Domingues V, Magder LS, Petri M. Assessment of the independent associations of IgG, IgM and IgA isotypes of anticardiolipin with thrombosis in SLE. Lupus Sci Med. 2016;3(1):e000107doi: 10.1136/lupus-2015-000107.
Domingues, V., Magder, L. S., & Petri, M. (2016). Assessment of the independent associations of IgG, IgM and IgA isotypes of anticardiolipin with thrombosis in SLE. Lupus science & medicine, 3(1), e000107. https://doi.org/10.1136/lupus-2015-000107
Domingues, Vinicius, et al. "Assessment of the independent associations of IgG, IgM and IgA isotypes of anticardiolipin with thrombosis in SLE." Lupus science & medicine vol. 3,1 (2016): e000107. doi: https://doi.org/10.1136/lupus-2015-000107
Domingues V, Magder LS, Petri M. Assessment of the independent associations of IgG, IgM and IgA isotypes of anticardiolipin with thrombosis in SLE. Lupus Sci Med. 2016 Jun 20;3(1):e000107. doi: 10.1136/lupus-2015-000107. eCollection 2016. PMID: 27403332; PMCID: PMC4932305.
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Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance.

Lupus science & medicine

Liu Y, Seto NL, Carmona-Rivera C, Kaplan MJ.
PMID: 29765617
Lupus Sci Med. 2018 May 14;5(1):e000259. doi: 10.1136/lupus-2018-000259. eCollection 2018.

OBJECTIVES: Activation of endosomal toll-like receptor (TLR)7 or TLR9 has been proposed as a critical step for the initiation and development of SLE. Traditional spontaneous lupus models normally introduce multiple risk alleles, thereby adding additional confounding factors. In the...

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Liu Y, Seto NL, Carmona-Rivera C, et al. Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance. Lupus Sci Med. 2018;5(1):e000259doi: 10.1136/lupus-2018-000259.
Liu, Y., Seto, N. L., Carmona-Rivera, C., & Kaplan, M. J. (2018). Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance. Lupus science & medicine, 5(1), e000259. https://doi.org/10.1136/lupus-2018-000259
Liu, Yudong, et al. "Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance." Lupus science & medicine vol. 5,1 (2018): e000259. doi: https://doi.org/10.1136/lupus-2018-000259
Liu Y, Seto NL, Carmona-Rivera C, Kaplan MJ. Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance. Lupus Sci Med. 2018 May 14;5(1):e000259. doi: 10.1136/lupus-2018-000259. eCollection 2018. PMID: 29765617; PMCID: PMC5950641.
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